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640006P

Avanti

DMABA-d6 NHS Ester

Avanti Research™ - A Croda Brand

Synonym(e):

4-(dimethylamino)benzoic acid N-hydroxysuccinimide ester-d6

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About This Item

Empirische Formel (Hill-System):
C13H8D6N2O4
CAS-Nummer:
1175002-04-6
Molekulargewicht:
268.30
UNSPSC-Code:
12352211
NACRES:
NA.25

Beschreibung

4-[di(methyl-d3)amino]-2,5-dioxo-1-pyrrolidinyl ester benzoic acid-d6

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (640006P-1mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

O=C(ON(C(CC1)=O)C1=O)C2=CC=C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C2

Allgemeine Beschreibung

The DMABA NHS ester reagents were developed by Dr. Robert Murphy′s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.

Biochem./physiol. Wirkung

Deuterium enriched 4-(dimethylamino) benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents (d0, d4, d6, d10) derivatize the primary amine group of lipids, such as glycerophosphoethanolamine (PE) lipid species.

Verpackung

5 mL Amber Glass Screw Cap Vial (640006P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

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Analysenzertifikate (COA)

Lot/Batch Number

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Gilbert O Fruhwirth et al.
Biochimica et biophysica acta, 1772(7), 718-736 (2007-06-16)
Oxidized lipids are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. The great variety of reaction products is defined by the degree of modification, hydrophobicity, chemical reactivity, physical properties and biological activity. The biological activities of
Marko Kosicek et al.
International journal of molecular sciences, 14(1), 1310-1322 (2013-01-12)
Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and sphingolipids) are important building blocks of cell membranes, which provide an optimal environment for protein interactions, trafficking and function. Because of that, alterations in their cellular levels
Karin A Zemski Berry et al.
Analytical chemistry, 81(16), 6633-6640 (2010-03-27)
A set of four (D(0), D(4), D(6), and D(10)) deuterium enriched 4-(dimethylamino)benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents was developed that react with the primary amine group of glycerophosphoethanolamine (PE) lipids to create derivatives where all subclasses of DMABA labeled
Yukiko Ueda et al.
Nutrition research (New York, N.Y.), 28(4), 239-244 (2008-12-17)
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
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