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P1101

Sigma-Aldrich

D-Penicillamindisulfid

97%, cell analysis

Synonym(e):

3,3′-Dithio-bis-(2-amino-3-methyl-buttersäure), S,S′-Bi-(D-penicillamin)

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About This Item

Lineare Formel:
[-SC(CH3)2CH(NH2)CO2H]2
CAS-Nummer:
20902-45-8
Molekulargewicht:
296.41
Beilstein:
4461521
EG-Nummer:
244-107-2
MDL-Nummer:
MFCD00004264
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24898153
NACRES:
NA.22

product name

D-Penicillamindisulfid, 97%

Assay

97%

Form

powder or crystals

Optische Aktivität

[α]25/D −75°, c = 1 in 1 M NaOH

Eignung der Reaktion

reaction type: solution phase peptide synthesis

Farbe

white

mp (Schmelzpunkt)

204 °C (dec.) (lit.)

Anwendung(en)

cell analysis

SMILES String

CC(C)(SSC(C)(C)[C@@H](N)C(O)=O)[C@@H](N)C(O)=O

InChI

1S/C10H20N2O4S2/c1-9(2,5(11)7(13)14)17-18-10(3,4)6(12)8(15)16/h5-6H,11-12H2,1-4H3,(H,13,14)(H,15,16)/t5-,6-/m0/s1

InChIKey

POYPKGFSZHXASD-WDSKDSINSA-N

Anwendung

Used in pharmacological studies of:
  • Molecules dermatomyositis activity
  • Antimelanoma activity of apoptogenic carbonyl scavengers

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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P Unak et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 49(7), 805-809 (1998-05-07)
Complex forming conditions of Penicillamine di sulfide with 99mTc have been specified. Labeling of penicillamine di sulfide with 99mTc by direct reduction with SnCl2 did not give favorable good results while the 99mTc complex of penicillamine can be easily obtained.
T F Yu et al.
The Journal of rheumatology, 11(4), 467-470 (1984-08-01)
Four patients with recurrent cystine stones and 5 with rheumatoid arthritis (RA) were studied. After a single dose of D-penicillamine to cystinuric patients, cystine excretion decreased considerably. Cysteine-penicillamine mixed disulfide (CSSP) and penicillamine disulfide (PSSP) metabolites appeared within 1-2 h
J K Nicholson et al.
Drug metabolism and drug interactions, 6(3-4), 439-446 (1988-01-01)
Preliminary studies on the use of high resolution 1H-NMR spectroscopy for the detection of the thiol drug penicillamine and its metabolites in human urine are described. The technique is rapid, simple and requires minimal sample pretreatment. Application of NMR to
K K Millis et al.
Biochimica et biophysica acta, 1055(1), 10-18 (1990-10-15)
The oxidation/reduction chemistry of penicillamine in human erythrocytes was characterized directly in intact erythrocytes by 1H-NMR spectroscopy. Spectra were measured by the Carr-Purcell-Meiboom-Gill pulse sequence to selectively eliminate interfering resonances from hemoglobin and membrane protons and from the intracellular water.
Y J Yang et al.
Occupational and environmental medicine, 51(4), 267-270 (1994-04-01)
Four workers chronically exposed to elemental mental mercury in a lampsocket manufacturing factory were studied. The clinical manifestations were severe in one, mild in another, and suspicious in the remaining two. Correlation between severity of clinical features and increased urinary
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