914746

Thiophosphoro alkyne dichloridate

≥95%

• Synonym(e): O-(Prop-2-yn-1-yl) phosphorodichloridothioate, Chemoselective histidine labeling reagent, Phosphorodichloridothioate 2-propyn-1-ol, Propargyl thiophosphorodichloridate, TPAC, Thiophosphoro alkyne dichloridate, Thiophosphorodichloridate reagent, Thiophosphorus electrophile
• Empirische Formel (Hill-System): C₃H₃Cl₂OPS
• CAS-Nummer: 21300-59-4
• Molekulargewicht: 189.00
• MDL-Nummer: MFCD32857301
• UNSPSC-Code: 12352106
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: liquid
• Lagertemp.: −20°C
• SMILES String: [P](=S)(Cl)(Cl)OCC#C
• InChI: 1S/C3H3Cl2OPS/c1-2-3-6-7(4,5)8/h1H,3H2
• InChIKey: HPJLQEFYLAALCL-UHFFFAOYSA-N

Beschreibung

Anwendung

Thiophosphoro alkyne dichloridate (TPAC) is a histidine labeling reagent developed by the Chang lab that mimics native post-translational His phosphorylation. The alkyne allows for subsequent reactions or addition of payloads by copper-assisted alkyne-azide cycloaddition (CuAAC) chemistry. TPAC was also demonstrated to covalently modify His-tags, and by clicking on polyarginine tags, enabled protein delivery into live cells.

Sonstige Hinweise

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): 175.8 °F
• Flammpunkt (°C): 79.9 °C