707066

DCA Deblock (0,36 M Dichloressigsäure in Toluol)

• Synonym(e): DCA-Deblock (0.36M Dichloressigsäure in Toluol), DEBLOCK (0.36M Dichloressigsäure in Toluol)
• Empirische Formel (Hill-System): C₂H₂Cl₂O₂
• CAS-Nummer: 79-43-6
• Molekulargewicht: 128.94
• MDL-Nummer: MFCD00004223
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 329762686

Eigenschaften

• Form: liquid
• Qualitätsniveau: 100
• Konzentration: ≤100 ppm in H₂O
• bp: 110-111 °C
• Dichte: 0.884 g/mL at 25 °C
• SMILES String: OC(=O)C(Cl)Cl
• InChI: 1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)
• InChIKey: JXTHNDFMNIQAHM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Anwendung

DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H304,H315,H318,H336,H351,H360FD,H362,H373,H412
• P-Sätze: P210 - P263 - P280 - P301 + P310 - P305 + P351 + P338 - P331
• Gefahreneinstufungen: Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 41.0 °F
• Flammpunkt (°C): 5 °C
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter