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Merck

TRPV4

transient receptor potential cation channel, subfamily V, member 4

Synonyme:
CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(59341) Summary: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
  • Mouse(63873) transient receptor potential cation channel, subfamily V, member 4
  • Rat(66026) transient receptor potential cation channel, subfamily V, member 4
  • naked mole-rat(101706710) transient receptor potential cation channel, subfamily V, member 4
  • domestic guinea pig(100724607) transient receptor potential cation channel, subfamily V, member 4
  • sheep(101113534) transient receptor potential cation channel, subfamily V, member 4
  • domestic cat(101084907) transient receptor potential cation channel, subfamily V, member 4
  • Horse(100066552) transient receptor potential cation channel, subfamily V, member 4
  • cow(540259) transient receptor potential cation channel, subfamily V, member 4
  • chicken(395427) transient receptor potential cation channel, subfamily V, member 4
  • dog(486308) transient receptor potential cation channel, subfamily V, member 4
  • Zebrafish(557850) transient receptor potential cation channel, subfamily V, member 4

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Spezies
rat, human
Pelargonsäure-vanillylamid, ≥97%, powder,
Spezies
rat

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
Capsazepine, ≥98% (HPLC), solid,
Spezies
human, rat
Capsaicin, ≥95%, from Capsicum sp.,
Spezies
rat, human
Capsaicin, natural,
Spezies
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Spezies
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophen, 96%,
Spezies
human, rat, mouse

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-TRPV4 Antibody, clone 1G10-L2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
canine, human, mouse, rat
Anwendung
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-Trpv4-Antikörper, Klon 1B2.6, clone 1B2.6, from mouse,
Speziesreaktivität
human, mouse
Anwendung
immunocytochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Speziesreaktivität
rat
Anwendung
western blot
Anti-Transient Receptor Potential Vanilloid 4 Antibody, pain, Chemicon®, from rabbit,
Speziesreaktivität
rat
Anwendung
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, rabbit
Anwendung
immunohistochemistry
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Butamben, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Capsaicin, ≥95%, from Capsicum sp.,
Spezies
rat, human
Capsaicin, natural,
Spezies
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Spezies
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophen, 96%,
Spezies
human, rat, mouse

Small Molecule - Mixed Agonist/Antagonist

Produktnummer
Beschreibung
Spezies
Pelargonsäure-vanillylamid, ≥97%, powder,
Spezies
rat
Capsazepine, ≥98% (HPLC), solid,
Spezies
human, rat

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting mouse Trpv4,
Spezies
mouse
MISSION® esiRNA, targeting human TRPV4,
Spezies
human