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Merck

GRIA4

glutamate receptor, ionotropic, AMPA 4

Synonyme:
GLUR4, GLUR4C, GLURD, GluA4
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(2893) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
  • Mouse(14802) glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Rat(29629) glutamate receptor, ionotropic, AMPA 4
  • sheep(443274) glutamate receptor, ionotropic, AMPA 4
  • domestic cat(101087003) glutamate receptor, ionotropic, AMPA 4
  • chicken(396137) glutamate receptor, ionotropic, AMPA 4
  • domestic guinea pig(100728256) glutamate receptor, ionotropic, AMPA 4
  • cow(529904) glutamate receptor, ionotrophic, AMPA 4
  • Horse(100061561) glutamate receptor, ionotropic, AMPA 4
  • dog(489427) glutamate receptor, ionotropic, AMPA 4
  • naked mole-rat(101698538) glutamate receptor, ionotropic, AMPA 4

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide, ≥98% (HPLC), solid,
Spezies
human
Cyclothiazid, ,
Spezies
human, rat
(±)-AMPA, solid,
Spezies
rat
(S)-AMPA, ≥97%,
Spezies
mouse, human, rat
Kainic acid monohydrate, ≥99% (TLC),
Spezies
human, mouse, rat

Small Molecule - Allosteric Modulator

Produktnummer
Beschreibung
Spezies
CX546, ≥98% (HPLC), solid,
Spezies
human
Piracetam, ,
Spezies
human, rat
Cyclothiazid, ,
Spezies
human, rat
Kainic acid monohydrate, ≥99% (TLC),
Spezies
human, mouse, rat
Topiramat, United States Pharmacopeia (USP) Reference Standard,
Spezies
human

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
GYKI 52466 hydrochloride, solid,
Spezies
human
Piracetam, ,
Spezies
human, rat
CNQX Dinatriumsalz Hydrat, ≥98% (HPLC), solid,
Spezies
human
NBQX Dinatriumsalz Hydrat, ≥98% (HPLC),
Spezies
human
(±)-AMPA, solid,
Spezies
rat

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Glutamatrezeptor 4-Antikörper, Chemicon®, from rabbit,
Speziesreaktivität
mouse, rat
Anwendung
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Gria4 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
Anti-GLUR4 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
western blot
Anti-GRIA4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
bovine, human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot

Small Molecule - Blocker

Produktnummer
Beschreibung
Spezies
Cyclothiazid, ,
Spezies
human, rat
Kynurensäure, ≥98%,
Spezies
rat, human
Topiramat, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human
Topiramat, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human

Small Molecule - Mixed Agonist/Antagonist

Produktnummer
Beschreibung
Spezies
Cyclothiazid, ,
Spezies
human, rat
(±)-AMPA, solid,
Spezies
rat
Kainic acid monohydrate, ≥99% (TLC),
Spezies
human, mouse, rat
L-Glutaminsäure, ReagentPlus®, ≥99% (HPLC),
Spezies
rat, human
L-Glutaminsäure, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Spezies
rat, human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human GRIA4,
Spezies
human
MISSION® esiRNA, targeting mouse Gria4,
Spezies
mouse