A0326

(S)-AMPA

≥98%

• Synonym(e): (S)-α-Amino-3-hydroxy-5-methylisoxazol-4-propionsäure
• Empirische Formel (Hill-System): C₇H₁₀N₂O₄
• CAS-Nummer: 83643-88-3
• Molekulargewicht: 186.17
• MDL-Nummer: MFCD00672630
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24890421
• NACRES: NA.77

Eigenschaften

• Assay: ≥98%
• Form: powder
• SMILES String: Cc1onc(O)c1C[C@H](N)C(O)=O
• InChI: 1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
• InChIKey: UUDAMDVQRQNNHZ-YFKPBYRVSA-N
• Angaben zum Gen: human ... GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) ; mouse ... Gria1(14799) ; rat ... Gria1(50592) , Gria2(29627) , Gria3(29628) , Gria4(29629) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grin2b(24410) , Grm6(24419)

Beschreibung

Allgemeine Beschreibung

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).

Anwendung

(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.

(S)-AMPA has been used to selectively eliminate the neural cochlear component of adult barn owls by destroying afferent synapses.

Biochem./physiol. Wirkung

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.

Leistungsmerkmale und Vorteile

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This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)