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Principaux documents

SRP0375

Sigma-Aldrich

LOXL2 human

recombinant, expressed in FreeStyle™ 293-F cells, ≥86% (SDS-PAGE)

Synonyme(s) :

LOR2, WS9-14, lysyl oxidase-like 2

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in FreeStyle™ 293-F cells

Essai

≥86% (SDS-PAGE)

Forme

aqueous solution

Poids mol.

85 kDa

Conditionnement

pkg of 10 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Concentration

0.23 mg/mL

Numéro d'accès NCBI

NM_002318

Numéro d'accès UniProt

Q9Y4K0

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... LOXL2(4017)

Description générale

Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.

Actions biochimiques/physiologiques

Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.

Forme physique

Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.

Informations légales

FreeStyle is a trademark of Invitrogen Corp.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H315,H319,H360D

Classification des risques

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
6051220213

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

The LOXL2 Gene Encodes a New Lysyl Oxidase-like Protein and Is Expressed at High Levels in Reproductive Tissues*
Claude Jourdan-Le Saux
The Journal of Biological Chemistry (1999)
Olivier G de Jong et al.
Journal of cellular and molecular medicine, 20(2), 342-350 (2015-11-28)
Exosomes are important mediators of intercellular communication. Additionally, they contain a variety of components capable of interacting with the extracellular matrix (ECM), including integrins, matrix metalloproteinases and members of the immunoglobin superfamily. Despite these observations, research on exosome-ECM interactions is
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression
Alberto Martin
The Embo Journal, 34(5), 1090-1109 (2015)
The function and mechanisms of action of LOXL2 in cancer (Review)
Linghong Wu and Ying Zhu
International Journal of Molecular Medicine, 1200-1204 (2015)
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma
Keiko Mizuno
International Journal of Oncology, 48(2), 450-460 (2016)
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