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T2879

Tyramine hydrochloride

Name: Tyramine hydrochloride
Brand: SIGMA

≥98% (TLC), powder, neuromodulator

Synonyme(s) :

4-(2-Aminoethyl)phenol hydrochloride, 4-Hydroxyphenethylamine hydrochloride, Tyrosamine hydrochloride

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A propos de cet article

Formule linéaire :

HOC₆H₄CH₂CH₂NH₂· HCl

Numéro CAS:

60-19-5

Poids moléculaire :

173.64

NACRES:

NA.77

PubChem Substance ID:

24277896

UNSPSC Code:

12352116

EC Number:

200-462-5

MDL number:

MFCD00012901

Beilstein/REAXYS Number:

3627058

Assay:

≥98%

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Propriétés

Nom du produit

Tyramine hydrochloride, ≥98%

Quality Segment

200

assay

≥98%

mp

271-274 °C (lit.)

solubility

H₂O: soluble 50 mg/ml, clear, colorless to faintly yellow

SMILES string

Cl[H].NCCc1ccc(O)cc1

InChI

1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H

InChI key

RNISDHSYKZAWOK-UHFFFAOYSA-N

Gene Information

human ... ADORA2A(135), ADORA2B(136), ADORA3(140)

Description

Application

Tyramine hydrochloride has been:

coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure[1]
labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis
used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification

Biochem/physiol Actions

Can enter catecholaminergic terminals and be released as a false transmitter.

Tyramine is a biogenic amine and a neuromodulator localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders. Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.

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Cet article	M4251	M6500	SML1924
Sigma-Aldrich T2879 Tyramine hydrochloride	Sigma-Aldrich M4251 3-Methoxytyramine hydrochloride	Sigma-Aldrich M6500 Cysteamine hydrochloride	Sigma-Aldrich SML1924 T1AM
assay ≥98%	assay ≥95.5%	assay ≥98% (titration)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 300	Quality Level 100
solubility H₂O: soluble 50 mg/ml, clear, colorless to faintly yellow	solubility -	solubility water: 50 mg/mL, clear, colorless to very faintly yellow	solubility H₂O: 10 mg/mL, clear
Gene Information human ... ADORA2A(135), ADORA2B(136), ADORA3(140)	Gene Information human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)	Gene Information -	Gene Information -
mp 271-274 °C (lit.)	mp 213-215 °C (lit.)	mp 67-71 °C	mp -

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Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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