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SML0031

Sigma-Aldrich

DBeQ

≥98% (HPLC)

Synonyme(s) :

JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine

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About This Item

Formule empirique (notation de Hill):
C22H20N4
Numéro CAS:
177355-84-9
Poids moléculaire :
340.42
Numéro MDL:
MFCD03691820
Code UNSPSC :
12352200
ID de substance PubChem :
329825101
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: ≥20 mg/mL

Température de stockage

room temp

Chaîne SMILES 

C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

InChI

1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

Clé InChI

QAIMUUJJAJBPCL-UHFFFAOYSA-N

Application

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Actions biochimiques/physiologiques

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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