S2876

Spermine tetrahydrochloride

powder or crystals, NMDA agonist/antagonist

• Synonyme(s) : N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• Formule empirique (notation de Hill): C₁₀H₂₆N₄ · 4HCl
• Numéro CAS: 306-67-2
• Poids moléculaire : 348.18
• Numéro Beilstein : 3911771
• Numéro CE : 206-189-8
• Numéro MDL: MFCD00012914
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278007
• Nomenclature NACRES : NA.77

Propriétés

• product name: Spermine tetrahydrochloride, powder or crystals
• Forme: powder or crystals
• Niveau de qualité: 200
• Pf: 310-311 °C (dec.) (lit.)
• Solubilité: water, high purity: 100 mg/ml
• Température de stockage: room temp
• Chaîne SMILES: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• Clé InChI: XLDKUDAXZWHPFH-UHFFFAOYSA-N
• Informations sur le gène: human ... GRIN1(2902)

Description

Application

Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.

Used to precipitate DNA from low salt aqueous buffers.

Actions biochimiques/physiologiques

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Spermine, a polyamine, is derived from spermidine and is required for cell growth in eukaryotes. It acts as regulator of gene expression, inhibits DNA damage and protects the cells from damage by acting as free radical scavenger. In proteomics studies, spermine mediates rapid crystallization of DNA-binding proteins.

Notes préparatoires

Spermine tetrahydrochloride yields clear, colorless to light yellow solution in water at 100 mg/ml.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319
• Conseils de prudence: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves