E7781

Erastin

≥98% (HPLC), powder, ferroptosis inducer

• Synonyme(s) : 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
• Formule empirique (notation de Hill) : C₃₀H₃₁ClN₄O₄
• Numéro CAS: 571203-78-6
• Poids moléculaire : 547.04
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799073
• NACRES: NA.77
• MDL number: MFCD09837984
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Erastin, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: CCOc1ccccc1N2C(=O)c3ccccc3N=C2C(C)N4CCN(CC4)C(=O)COc5ccc(Cl)cc5
• InChI: 1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
• InChI key: BKQFRNYHFIQEKN-UHFFFAOYSA-N
• Gene Information: human ... hRas(3265) ; mouse ... hRas(15461) ; rat ... hRas(293621)

Description

General description

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc^-.

Application

Erastin has been used:

• as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)
• to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells
• to induce ferroptosis of muscle-derived cell lines

Biochem/physiol Actions

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges