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N-tert-butyldiméthylsilyl-N-méthyltrifluoroacétamide

for GC derivatization, LiChropur™, ≥98.0% (GC)

Synonyme(s) :

MTBSTFA

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About This Item

Formule linéaire :
CF3CON(CH3)Si(CH3)2C(CH3)3
Numéro CAS:
77377-52-7
Poids moléculaire :
241.33
Numéro Beilstein :
3606546
Numéro MDL:
MFCD00009671
Code UNSPSC :
12352111
Nomenclature NACRES :
NA.22

Qualité

for GC derivatization
LiChropur™

Pureté

≥98.0% (GC)

Forme

liquid

Pertinence de la réaction

reagent type: derivatization reagent
reaction type: Silylations

Technique(s)

gas chromatography (GC): suitable

Indice de réfraction

n20/D 1.402 (lit.)

Point d'ébullition

172-175 °C (lit.)

Densité

1.036 g/mL at 25 °C (lit.)

Température de stockage

2-8°C

Chaîne SMILES 

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

Clé InChI

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

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Description générale

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a silylating reagent which replaces the active hydrogen with tert-Butyldimethylsilyl group. The tert-Butyldimethylsilyl derivatives are found to be more resistant to hydrolysis and stable compared to trimethylsilyl (TMS) derivatives. This reagent is suitable for GC-MS analysis since it produces mass spectra, which can be easily interpreted. It is widely used for the silylation of different alcohols, thiols, phenols, carboxylic acids, amines, and amides.

Application

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide may be used as a derivatizing reagent for the determination of methionine sulfoxide and methionine in blood plasma and chlorpyrifos, diazinon and their major metabolites in sludge and sludge-fertilized agricultural soils using gas-chromatography coupled to mass spectrometry technique.

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Informations légales

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

394882

N-tert-butyldiméthylsilyl-N-méthyltrifluoroacétamide, >97%

190500

tert-Butyldimethylsilyl chloride, reagent grade, 97%

375934

N-tert-butyldiméthylsilyl-N-méthyltrifluoroacétamide avec 1 % de tert-Butyldiméthylchlorosilane, ≥95%

473464

tert-Butylchlorodimethylsilane solution, 50 wt. % in toluene

384429

tert-Butyldimethylsilyl chloride solution, 1.0 M in methylene chloride

372951

tert-Butyldimethylsilyl chloride solution, 1.0 M in THF

226149

tert-Butyldimethylsilyl trifluoromethanesulfonate, reagent grade, 98%

250236

1-(tert-Butyldiméthylsilyl)imidazole, ≥95%

06735

tert-Butyldimethylsilyl chloride, for GC derivatization, LiChropur™, ≥99.0% (GC)

56563

tert-Butyldimethylsilyl trifluoromethanesulfonate, for GC derivatization, LiChropur™, ≥98.0% (T)

00942

N-tert-butyldiméthylsilyl-N-méthyltrifluoroacétamide avec 1 % de tert-Butyldiméthylchlorosilane, for GC derivatization, LiChropur™, ≥95.0% (GC)

44795

N,O-Bis(tert-butyldimethylsilyl)acetamide, for GC derivatization, LiChropur™, ≥98.0% (GC)

Pictogrammes

Flame
GHS02

Mention d'avertissement

Warning

Mentions de danger

H226

Classification des risques

Flam. Liq. 3

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

113.0 °F - closed cup

Point d'éclair (°C)

45 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number
BCCL5595
BCCK4857
BCCK1127
BCCH9690
BCCG8319

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Advanced Gas Chromatography: Progress in Agricultural, Biomedical and Industrial Applications (2012)
Highly selective sample preparation and gas chromatographic?mass spectrometric analysis of chlorpyrifos, diazinon and their major metabolites in sludge and sludge-fertilized agricultural soils
Diaz-Cruz SM and Barcelo D
Journal of Chromatography A, 1132(1-2), 21-27 (2006)
Ryuichi Mashima et al.
Analytical biochemistry, 313(1), 28-33 (2003-02-11)
Methionine sulfoxide is an oxidation product of methionine with reactive oxygen species via 2-electron-dependent mechanism. Such oxidants can be generated from activated neutrophils; therefore, methionine sulfoxide can be regarded as a biomarker of oxidative stress in vivo. We describe here
Two stage derivatization with N-(tert.-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) and N-methyl-bis-(trifluoroacetamide)(MBTFA) for the gas-chromatographic analysis of OH-, SH-and NH-compounds
Schoene K, et al.
Fresenius Journal of Analytical Chemistry, 348(5-6), 364-370 (1994)

Articles

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Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

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