1.08212

Poloxamère 188

(stabilized with 70ppm BHT), EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Synonyme(s) : Poloxamer 188
• Formule linéaire : (C₃H₆O · C₂H₄O)_x
• Numéro CAS: 9003-11-6
• Numéro MDL: MFCD00082049
• Code UNSPSC : 12352112

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 500
• Agence: NF; Ph. Eur.
• Gamme de produits: EMPROVE^® ESSENTIAL
• Point d'ébullition: >150 °C
• Pf: 55 °C
• Masse volumique apparente: 1050 kg/m³
• Température de stockage: 2-25°C
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• Clé InChI: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

Description générale

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid oral dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Parteck^® PLX 188 excipient combines adequate lubrication at tolerable concentrations with the added benefit of dissolution enhancement. It features consistent performance, improved dissolution rate and reliable lubrication – all at the same time. As a result, Parteck^® PLX 188 excipient can therefore provide a simple solution to low bioavailability of DCS 2a compounds.

Caractéristiques et avantages

• Hydrophilic, water-soluble tablet lubrication
• Improved dissolution rates for poorly soluble DCS class IIa molecules
• Specified particle size distribution optimized for solid application performance
• Regulatory support through compliance with Ph. Eur. and USP-NF, going beyond current requirements with specitied formaldehyde content

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable