04-259
Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18
clone S5a-18, Upstate®, from mouse
Synonyme(s) :
S5a
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
S5a-18, monoclonal
Espèces réactives
human
Fabricant/nom de marque
Upstate®
Technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PSMD4(5710)
Description générale
Rpn10 (S5a) is a non-ATPase subunit of the 19S regulatory complex of the 26s proteasome. Subunit Rpn10 (S5a) of the 26S proteasome was originally identified as a protein capable of binding poly-ubiquitin chains of four or more ubiquitins, in the absence of other 26S proteasome subunits.
Spécificité
Recognizes 19S regulator non-ATPase subunit S5a/Rpn10.
Immunogène
Full length human recombinant Rpn10 protein.
Application
Detect 19S regulator non-ATPase subunit S5a/Rpn10 using this Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18 validated for use in IP & WB.
Research Category
Protein Trafficking
Protein Trafficking
Research Sub Category
Ubiquitin & Ubiquitin Metabolism
Ubiquitin & Ubiquitin Metabolism
Description de la cible
41 kDa
Forme physique
100 µL of purified immunoglobulin in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Format: Purified
Stockage et stabilité
Stable for 1 year at -20°C from date of shipment for up to 12 months.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Kylie J Walters et al.
Biochemistry, 41(6), 1767-1777 (2002-02-06)
The 26S proteasome is essential for the proteolysis of proteins that have been covalently modified by the attachment of polyubiquitinated chains. Although the 20S core particle performs the degradation, the 19S regulatory cap complex is responsible for recognition of polyubiquitinated
Purification of poly-ubiquitinated proteins by S5a-affinity chromatography
Layfield, R, et al
Proteomics, 1, 773-777 (2001)
Anna J Slezak et al.
ACS central science, 8(10), 1435-1446 (2022-11-01)
Immune stimulating agents like Toll-like receptor 7 (TLR7) agonists induce potent antitumor immunity but are limited in their therapeutic window due to off-target immune activation. Here, we developed a polymeric delivery platform that binds excess unpaired cysteines on tumor cell
Yuqing Lei et al.
STAR protocols, 3(1), 101035-101035 (2022-01-04)
Palmitoylation is a special kind of lipid modification that targets proteins to membranes. This protocol introduces the acyl-biotin exchange (ABE) assay to determine the palmitoylation of protein cysteines in yeast. Palmitoylation is exchanged by biotinylated compounds so that the palmitoyl proteins
C R Wilkinson et al.
Nature cell biology, 3(10), 939-943 (2001-10-05)
The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin-proteasome system. We describe the isolation of a fission-yeast gene, mud1+, which encodes a UBA domain containing protein that is able
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