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A-075

Supelco

Androstenedione solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C19H26O2
Numéro CAS:
63-05-8
Poids moléculaire :
286.41
Numéro MDL:
MFCD00178626
Code UNSPSC :
41116107
ID de substance PubChem :
329770627
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

300

Forme

liquid

Caractéristiques

SNAP-N-SPIKE®, SNAP-N-SHOOT®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in acetonitrile

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

O=C1C=C2CCC3C4C(C(CC4)=O)(C)CCC3C2(C)CC1

InChI

1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3

Clé InChI

AEMFNILZOJDQLW-UHFFFAOYSA-N

Description générale

Androstenedione is a hormone and intermediate in the biochemical pathway for producing testosterone, estrone, and estradiol. This Certified Spiking Solution® is suitable for use as starting material in linearity standards, calibrators, and controls for numerous LC/MS and GC/MS applications in endocrinology, clinical chemistry, neonatal screening, and sports testing.

Application

<ul>
<li><strong>Steroid biosynthesis studies:</strong> The utility of androstenedione solution in dried blood spot analysis via liquid chromatography tandem mass spectrometry is highlighted, providing a method applicable for newborn screening for congenital adrenal hyperplasia and other steroid-related disorders (Zhan et al., 2022).</li>
<li><strong>Hormone precursor biochemical research:</strong> A method for the simultaneous measurement of testosterone, androstenedione, and dehydroepiandrosterone in human serum using liquid chromatography-tandem mass spectrometry was developed, supporting research in hormone biosynthesis and metabolism (Xu et al., 2017).</li>
<li><strong>Anabolic steroid research:</strong> A study on the application of a UHPLC-MS/MS method for the determination of 17 steroidal hormones, including androstenedione, in equine serum, is crucial for advancing research in doping and physiological studies (Genangeli et al., 2017).
</ul>

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

FlameExclamation mark
GHS02,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

35.6 °F - closed cup

Point d'éclair (°C)

2 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Hidetaka Tasaki et al.
Theriogenology, 79(5), 809-814 (2013-01-26)
Antrum formation and estradiol (E2) secretion occur during early folliculogenesis. The objective was to determine the role of E2 in antrum formation of oocyte-granulosa cell complexes (OGCs) derived from porcine preantral follicles (PAFs). Supplementation of the culture medium with E2
S N Schauer et al.
Theriogenology, 79(3), 409-416 (2012-12-04)
There is evidence in several species that high circulating LH concentrations can interfere with normal follicle development and ovulation. In the mare, high LH levels after induction of luteolysis with PGF(2α) have been temporally associated with an increased incidence of
Annette Mouritsen et al.
The Journal of clinical endocrinology and metabolism, 98(3), E605-E609 (2013-02-09)
Longer androgen receptor gene CAG trinucleotide repeats, AR (CAG)n, have been associated with reduced sensitivity of the androgen receptor (AR) in vitro as well as in humans. Furthermore, short AR (CAG)n have been associated with premature adrenarche. The aim of
Ewa Łucja Gregoraszczuk et al.
Reproduction (Cambridge, England), 145(3), 311-317 (2013-04-13)
Evidence from both clinical and animal studies suggests that exposure to excess androgens results in cyst formation. The present in vitro study assessed the effects of supraphysiological concentrations of leptin (20 and 40 ng/ml) on progesterone (P(4)), androstenedione androstendione (A(4))
Wenqing Zhang et al.
The Journal of steroid biochemistry and molecular biology, 135, 36-42 (2013-01-10)
The enzyme 3-ketosteroid-Δ(1)-dehydrogenase (KSDD), involved in steroid metabolism, catalyzes the transformation of 4-androstene-3,17-dione (AD) to androst-1,4-diene-3,17-dione (ADD) specifically. Its coding gene was obtained from Mycobacterium neoaurum JC-12 and expressed on the plasmid pMA5 in Bacillus subtilis 168. The successfully expressed
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