T1500

Testosterone

≥98%

• Synonyme(s) : 17β-hydroxy-3-oxo-4-androstène, 4-androstène-17β-ol-3-one, trans-testostérone
• Formule empirique (notation de Hill): C₁₉H₂₈O₂
• Numéro CAS: 58-22-0
• Poids moléculaire : 288.42
• Numéro Beilstein : 1915399
• Numéro CE : 200-370-5
• Numéro MDL: MFCD00003654
• Code UNSPSC : 51111800
• ID de substance PubChem : 24899970
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Stérilité: non-sterile
• Pureté: ≥98%
• Forme: powder
• Contrôle du médicament: USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
• Solubilité: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml; absolute ethanol: soluble 0.5 mg/ml; chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow; H₂O: insoluble; dioxane: soluble; methanol: soluble; methyl oleate: slightly soluble; vegetable oils: soluble
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
• InChI: 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
• Clé InChI: MUMGGOZAMZWBJJ-DYKIIFRCSA-N
• Informations sur le gène: human ... AR(367) , EBP(10682) , ESR1(2099) , PGR(5241) , SERPINA6(866) , SHBG(6462) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890) , Nr3c1(24413) , Nr3c2(25672) , Pgr(25154)

Description

Application

Testosterone has been used as a standard to study the developmental profile of steroid hormones in male and female rat brains. This hormone has also been used to evaluate its effects on muscle mass and signaling in mice.

Actions biochimiques/physiologiques

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

Testosterone dissolves in chloroform at 100 mg/ml to yield a clear, colorless to very faint yellow solution. It is also soluble in methanol, absolute ethanol (0.5 mg/ml), 45 percent (w/v) aqueous 2-hydroxypropyl-b-cyclodextrin (18.2 mg/ml), vegetable oils and dioxane. It is slightly soluble in methyl oleate and insoluble in water.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H351,H360FD,H400
• Conseils de prudence: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges