BMS-303141 has been used for inhibition of ATP citrate lyase in breast cancer cell lines.[1]
Actions biochimiques/physiologiques
BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL).
BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.
Science (New York, N.Y.), 367(6473), 45-51 (2019-12-07)
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Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
