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L7393

Sigma-Aldrich

Leu-Leu methyl ester hydrobromide

≥97% (TLC)

Synonyme(s) :

LLME, HBr, Leu-Leu-Ome, HBr

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About This Item

Formule empirique (notation de Hill):
C13H26N2O3 · HBr
Numéro CAS:
16689-14-8
Poids moléculaire :
339.27
Numéro MDL:
MFCD00216855
Code UNSPSC :
12352209
ID de substance PubChem :
24896476
Nomenclature NACRES :
NA.26

product name

Leu-Leu methyl ester hydrobromide, ≥97% (TLC)

Pureté

≥97% (TLC)

Forme

powder

Couleur

white

Température de stockage

−20°C

Chaîne SMILES 

Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C

InChI

1S/C13H26N2O3.BrH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5;/h8-11H,6-7,14H2,1-5H3,(H,15,16);1H

Clé InChI

QIPBCIHWFATZOF-UHFFFAOYSA-N

Application


  • VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.: The article discusses the maintenance of lysosomal function and transcription factor activity in muscle cells, which may be influenced by small molecular agents like Leu-Leu methyl ester hydrobromide that affect cellular processes (Arhzaouy et al., 2019).

Actions biochimiques/physiologiques

Leu-Leu methyl ester (LLME, Leu-Leu-OMe) may be used to induce protease-dependent cell death (apoptosis) in immune cells such as mast cells, phagocytes, monocytes/macrophages and natural killer cells.
Peptide toxic to natural killer T cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

A Poloni et al.
Leukemia, 20(2), 329-335 (2005-12-13)
The engraftment ability of mesenchymal cells was investigated in 26 patients receiving allogeneic transplantation from HLA-identical siblings with reduced-intensity conditioning (RIC). The stem cell source was bone marrow (BM) in eight patients and G-CSF-mobilized peripheral blood hematopoietic cells in 18
F R Melo et al.
Scandinavian journal of immunology, 74(4), 354-362 (2011-06-08)
Mast cells (MC) have pathogenic roles in numerous disorders, and strategies that stabilize MC or induce MC apoptosis are therefore emerging as possible therapeutic regimens. A typical feature of MC is their high content of secretory lysosomes (granules), containing numerous
Chrisovalantis Papadopoulos et al.
The EMBO journal, 36(2), 135-150 (2016-11-01)
Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates
M Odaka et al.
Photochemistry and photobiology, 63(6), 800-806 (1996-06-01)
L-Leucyl-L-leucine methyl ester (Leu-Leu-OMe), an apoptosis inducer in natural killer cells and macrophages, was caged with trans-o-hydroxycinnamoyl (3a-d), trans-o-mercaptocinnamoyl (4) and o-nitrobenzyl derivatives (5a, b), and the photochemical reactivity of these derivatives in phosphate-buffered saline containing 1% dimethyl sulfoxide and
Catherina H Bird et al.
Biological chemistry, 391(8), 999-1004 (2010-06-12)
Reporter proteins comprising granzyme B (GrB) fused to eGFP, ecliptic pHluorin or mCherry, were generated and used to study granule (lysosome) distribution and properties in COS-1 cells and natural killer cells. The reporters resembled native GrB in biosynthesis and localization
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