F7930
FGFR3 (397-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonyme(s) :
Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4
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10 μG
698,00 $
698,00 $
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10 μG
698,00 $
About This Item
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32
698,00 $
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Source biologique
human
Niveau de qualité
Produit recombinant
expressed in baculovirus infected Sf9 cells
Gamme de produits
PRECISIO® Kinase
Essai
≥70% (SDS-PAGE)
Forme
buffered aqueous glycerol solution
Activité spécifique
95-129 nmol/min·mg
Poids mol.
~73 kDa
Conditionnement
pkg of 10 μg
Technique(s)
cell based assay: suitable
Solubilité
water: soluble
Numéro d'accès Protein ID
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... FGFR3(2261)
Description générale
Research area: Cancer
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.[2]
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.[2]
Actions biochimiques/physiologiques
FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. [3] This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma [3] and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.[4]Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. [3] FGFR3 also plays hepatoprotective function during liver damage. [5]
Forme physique
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Informations légales
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Corine G M L'Hôte et al.
Experimental cell research, 304(2), 417-431 (2005-03-08)
FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism.
Lin Chen et al.
Frontiers in bioscience : a journal and virtual library, 10, 1961-1976 (2005-03-17)
Fibroblast growth factor receptors (FGFRs) exist as a gene family of 4 membrane bound receptor tyrosine kinases (FGFR1-4) that mediate signals of at least 22 fibroblast growth factors (FGF1-22). FGFs/FGFRs play important roles in multiple biological processes, including mesoderm induction
Hiroko Tamagaki et al.
Biochemistry, 53(30), 5000-5007 (2014-07-11)
Activation of the protein tyrosine kinase receptors requires the coupling of ligand binding to a change in both the proximity and orientation of the single transmembrane (TM) helices of receptor monomers to allow transphosphorylation of the receptor kinase domain. We
FGFR3 biology and skeletal disease
Jyoti Narayana and William A Horton
Connective tissue research, 56(6), 427-433 (2015)
Elizabeth A Guancial et al.
Cancer medicine, 3(4), 835-844 (2014-05-23)
While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive disease. FGFR3 protein and mRNA expression, mutational status, and copy number
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