01810

Cycloheximide

≥90% (HPLC)

• Synonyme(s) : 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Formule empirique (notation de Hill): C₁₅H₂₃NO₄
• Numéro CAS: 66-81-9
• Poids moléculaire : 281.35
• Beilstein: 88868
• Numéro CE : 200-636-0
• Numéro MDL: MFCD00082346
• Code UNSPSC : 51102829
• ID de substance PubChem : 329747360
• Nomenclature NACRES : NA.85

Propriétés

• Source biologique: microbial
• Niveau de qualité: 200
• Essai: ≥90% (HPLC)
• Forme: powder or crystals
• Couleur: white to light beige
• Spectre d'activité de l'antibiotique: fungi; yeast
• Mode d’action: protein synthesis | interferes
• Chaîne SMILES: N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Clé InChI: YPHMISFOHDHNIV-FSZOTQKASA-N
• Informations sur le gène: human ... FKBP1A(2280) , PIN1(5300)

Description

Application

Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis[1][2] for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques,[3] activate cumulus-free equine oocytes,[4] and to have neuroprotective properties.[5]

Actions biochimiques/physiologiques

Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome.[6]

Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Conditionnement

1G, 5G

Autres remarques

Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H300,H341,H360D,H411
• Conseils de prudence: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Classification des risques: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges