137141

Spermine tetrahydrochloride

EMPROVE^® EVOLVE

• Synonyme(s) : N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• Formule empirique (notation de Hill): C₁₀H₂₆N₄ · 4HCl
• Numéro CAS: 306-67-2
• Poids moléculaire : 348.18
• Numéro Beilstein : 3911771
• Numéro MDL: MFCD00012914
• Code UNSPSC : 12352116

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 400
• Agence: non-compendial
• Forme: powder
• Concentration: 99.0-101.0 % (w/w) (T)
• Impuretés: ≤5000 mg/kg ethanol (HS-GC); ≤890 mg/kg toluene (HS-GC)
• Pf: 310-311 °C (dec.) (lit.)
• Traces de cations: Al: ≤25 mg/kg; Cr: ≤2.5 mg/kg; Cu: ≤25 mg/kg; Fe: ≤130 mg/kg; Ni: ≤2.5 mg/kg; Zn: ≤130 mg/kg
• Adéquation: corresponds for identity (¹H-NMR)
• Application(s): pharma/biopharma processes
• Chaîne SMILES: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• Clé InChI: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Description

Description générale

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

Used to precipitate DNA from low salt aqueous buffers.

Actions biochimiques/physiologiques

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315 - H319
• Conseils de prudence: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable