700001P

DC-Cholesterol HCl

Avanti Research^™ - A Croda Brand 700001P, powder

• Synonyme(s) : 3β-[N-(N′,N′-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride
• Formule empirique (notation de Hill) : C₃₂H₅₇N₂O₂Cl
• Numéro CAS: 166023-21-8
• Poids moléculaire : 537.26
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Essai: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 1 g (700001P-1g); pkg of 1 × 200 mg (700001P-200mg); pkg of 1 × 25 mg (700001P-25mg); pkg of 1 × 500 mg (700001P-500mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand 700001P
• Application(s): vaccine development
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [H][C@](C1)(OC(NCC[N+](C)([H])C)=O)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](C)CCCC(C)C.[Cl-]
• InChI: 1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H
• Clé InChI: ISXSJGHXHUZXNF-UHFFFAOYSA-N

Description

Description générale

DC-Cholesterol HCl is a cholesterol derivative and a cationic lipid[1] with a head group and linker moiety.[2]

DC-Cholesterol HCl is a sterol-based transfection reagent.

Application

DC-Cholesterol HCl is suitable:

• for the preparation of ultrasound cationic microbubbles[3]
• to prepare liposomes[4]
• for the preparation of L-glutathione (GSH), loaded proliposomes[5]

DC-Cholesterol HCl may be used in the preparation of colloidal dispersions for transmission electron microscopy studies.[1] It may also be used in liposome preparation for assessing hexokinase activity,[6] poly (lactic-coglycolicacid) loading[7] and in mRNA transfection studies.[8]

Actions biochimiques/physiologiques

DC-Cholesterol is an effective transfection agent and a liposome reagent.[2] Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection.[9] It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).[3]

DC-cholesterol is a cationic lipid, known to be the most efficient in gene transfection study.[10][11]

Conditionnement

20 mL Clear Glass Screw Cap Vial (700001P-1g)

20 mL Clear Glass Screw Cap Vial (700001P-500mg)

5 mL Amber Glass Screw Cap Vial (700001P-200mg)

5 mL Amber Glass Screw Cap Vial (700001P-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable