- Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water.
Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water.
Nature communications (2015-03-11)
Wenbo Liu, Lu Li, Chao-Jun Li
PMID25754344
RESUMO
Methods to assemble alkynes are essential for synthesizing fine chemicals, pharmaceuticals and polymeric photo-/electronic materials. Using light as a clean energy form and water as a green solvent has the potential to make synthetic chemistry more environmentally friendly. Here we present a transition-metal-free coupling protocol between aryl alkyne and alkyl iodide enabled by photoenergy in water. Under ultraviolet irradiation and in basic aqueous media, aryl alkynes efficiently couple with a wide range of alkyl iodides including primary, secondary and tertiary ones under mild conditions. A tentative mechanism for the coupling is also proposed.
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