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  • [Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].

[Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].

Biomeditsinskaia khimiia (2013-05-09)
V O Tkachev, M V Zaĭkovskaia, A V Troitskiĭ, N G Luzgina, V A Shkurupiĭ
PMID23650725
RESUMO

The effects of oxidized dextrans of different molecular weight on reactive oxygen species production and transmembrane mitochondrial potential of macrophages and neutrophils have been studied in vivo and in vitro. Oxidised dextrans demonstrated moderate direct antioxidant ability but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.

MATERIAIS
Número do produto
Marca
Descrição do produto
31390
Sigma-Aldrich
Dextran, Mr ~70,000
31392
Sigma-Aldrich
Dextran, Mr 450,000-650,000
31389
Sigma-Aldrich
Dextran, Mr ~40,000
D5376
Sigma-Aldrich
Dextrana, average mol wt 1,500,000-2,800,000
D8821
Sigma-Aldrich
Dextrana, average mol wt 60,000-76,000
D1662
Sigma-Aldrich
Dextrana, average mol wt 35,000-45,000
D9260
Sigma-Aldrich
Dextrana, average mol wt 9,000-11,000
31388
Sigma-Aldrich
Dextran, Mr ~6,000
00271
Supelco
Dextran, analytical standard, for GPC, 25,000
D4876
Sigma-Aldrich
Dextrana, average mol wt 150,000
00269
Supelco
Dextran, analytical standard, for GPC, 5,000
09184
Sigma-Aldrich
Dextran, Mr ~100,000
00268
Supelco
Dextran, analytical standard, for GPC, 1,000
31387
Sigma-Aldrich
Dextran, Mr 15,000-25,000
31397
Sigma-Aldrich
Dextrana, Mr ~60,000
31398
Sigma-Aldrich
Dextrana, Mr ~200,000
31394
Sigma-Aldrich
Dextran, enzymatic synth.
I3377
Supelco
Isoniazid, analytical standard, ≥99% (TLC)
D3759
Sigma-Aldrich
Dextrana, average mol wt 48,000-90,000
D4626
Sigma-Aldrich
Dextrana, average mol wt 15,000-30,000
31425
Supelco
Dextrana, analytical standard, for GPC, Mw 670,000
31417
Supelco
Dextrana, analytical standard, for GPC, Mw 5,000
D8802
Sigma-Aldrich
Dextran solution from Leuconostoc mesenteroides, 20 % (w/w) (Autoclaved)
31430
Supelco
Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
00894
Supelco
Dextran, analytical standard, for GPC, 270,000
00892
Supelco
Dextran, analytical standard, for GPC, 80,000
31419
Supelco
Dextrana, analytical standard, for GPC, Mw 25,000
00891
Supelco
Dextran, analytical standard, for GPC, 50,000
31416
Supelco
Dextrana, analytical standard, for GPC, Mw 1,000
00893
Supelco
Dextran, analytical standard, for GPC, 150,000