D9260

Dextrana

average mol wt 9,000-11,000

• Fórmula linear: (C₆H₁₀O₅)_n
• Número CAS: 9004-54-0
• Número CE: 232-677-5
• Número MDL: MFCD00130935
• Código UNSPSC: 12352201
• NACRES: NA.25

Propriedades

• fonte biológica: bacterial (Leuconostoc mesenteroides)
• Formulário: powder
• atividade óptica: [α]/D 199°
• peso molecular: average mol wt 9,000-11,000
• solubilidade: water: 0.1 g/mL, colorless to faintly yellow
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O
• InChI: 1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2
• chave InChI: FZWBNHMXJMCXLU-UHFFFAOYSA-N

Descrição

Aplicação

O uso de dextranas como braços espaçadores longos e hidrofílicos melhora o desempenho das proteínas imobilizadas que agem sobre macromoléculas.

Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. They may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems.[1]
Dextrans of less than 60,000Da are generally considered low molecular weight dextrans. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their viscosities, aggregation and permeation properties. High molecular weight, water-soluble, dextran polymers have been used in a wide variety of biomedical applications. Dextran (9,000-11,000), a low molecular weight dextran, may be used to study processes such as transient plasma membrane and blood brain barrier (BBB) permeabilization. It may be used as a sugar based crowding agent in protein packing and folding studies.[2]

Nota de preparo

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115^oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

Outras notas

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)