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PHL89593

Camptothecin

phyproof® Reference Substance

Sinônimo(s):

(S)-(+)-Camptothecin

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About This Item

Fórmula empírica (Notação de Hill):
C20H16N2O4
Número CAS:
7689-03-4
Peso molecular:
348.35
Beilstein:
631069
Número MDL:
MFCD00081076
Código UNSPSC:
41116107
NACRES:
NA.24

grau

primary reference standard

linha de produto

phyproof® Reference Substance

Ensaio

≥90.0% (HPLC)

forma

powder

fabricante/nome comercial

PhytoLab

pf

260 °C (dec.) (lit.)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O

InChI

1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

chave InChI

VSJKWCGYPAHWDS-FQEVSTJZSA-N

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Descrição geral

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Aplicação




  • Co-delivery system for camptothecin and doxorubicin: Research on dendritic polymer prodrug-based unimolecular micelles demonstrated a pH-responsive co-delivery mechanism for camptothecin and doxorubicin, offering a synergistic effect in controlled drug release (Chen and Liu, 2024).


  • Investigation into camptothecin′s role in chronic myeloid leukemia: The study explored the therapeutic potential of FL118, a camptothecin derivative, against chronic myeloid leukemia resistant to BCR-ABL inhibitors, targeting RNA helicase DDX5 (Takeda et al., 2024).


Informações legais

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Frases de perigo

H301,H340

Classificações de perigo

Acute Tox. 3 Oral - Muta. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Choose from one of the most recent versions:

Certificados de análise (COA)

Lot/Batch Number
73551
113560738
110163746

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Raju Suresh Kumar et al.
Saudi journal of biological sciences, 27(12), 3290-3300 (2020-12-12)
A small library of cage-like heterocyclic hybrids encompassing pyrroloisoquinolines, pyridinone and acenaphthene structural moieties have been synthesized and tested for their potential as anticancer agents against HCT116 and JURKAT cell lines. The results revealed that these cell lines are more
Katerina D Fagan-Solis et al.
Cell reports, 30(5), 1385-1399 (2020-02-06)
The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model
Jun Ho Ko et al.
Cell reports, 33(12), 108543-108543 (2020-12-29)
DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone lesion bypass pathway. RAD51 is the recombinase for HR. The

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