U8881

UCL 1684 ditrifluoroacetate hydrate

• Sinônimo(s): 6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
• Fórmula linear: (C₃₄H₃₀N₄)²⁺ · (C₂F₃O₂^-)₂ · xH₂O
• Número CAS: 201147-19-5
• Peso molecular: 720.66 (anhydrous basis)
• Código UNSPSC: 12352200
• ID de substância PubChem: 24900684
• NACRES: NA.77

Propriedades

• cor: white to off-white
• solubilidade: DMSO: 10 mg/mL
• cadeia de caracteres SMILES: [H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7
• InChI: 1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;
• chave InChI: YROHEYZVNZITJN-DDVHGCDCSA-N

Descrição

Aplicação

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair[1]. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries[2].

Ações bioquímicas/fisiológicas

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca²⁺-activated K⁺ channel.[3] It comprises two quinolinium rings and is similar to apamin arginine residue.[4] UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.[5]

Características e benefícios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)