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T2452

Sigma-Aldrich

Talsaclidine

≥98% (HPLC), oil

Sinônimo(s):

(R)-3-(2-Propynyloxy)-1-Azabicyclo[2.2.2]octane, WAL 2014

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About This Item

Fórmula empírica (Notação de Hill):
C10H15NO
Número CAS:
147025-53-4
Peso molecular:
165.23
Código UNSPSC:
12352204
ID de substância PubChem:
329826707
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

oil

solubilidade

DMSO: >5 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C#CCO[C@H]1CN2CC[C@H]1CC2

InChI

1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1

chave InChI

XVFJONKUSLSKSW-JTQLQIEISA-N

Ações bioquímicas/fisiológicas

Talsaclidine aids in promoting the nonamyloidogenic α-secretase pathway in model systems. It is more effective in stimulating muscarinic M 1 receptors than M 2 and M 3 receptors. In anesthetized guinea pigs, talsaclidine has no bronchospastic effects, but it produces contracture in isolated tracheal muscle. Talsaclidine is considered a potential candidate for cholinergic replacement therapy.
Talsaclidine is a M1 selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.

Características e benefícios

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Embalagem

Packaged under argon

Nota de preparo

Talsaclidine is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Pictogramas

Corrosion
GHS05

Palavra indicadora

Danger

Frases de perigo

H318

Declarações de precaução

P280 - P305 + P351 + P338

Classificações de perigo

Eye Dam. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

A Walland et al.
European journal of pharmacology, 330(2-3), 213-219 (1997-07-09)
The aim of the present investigation was to determine the reasons why the muscarinic receptor agonist talsaclidine (WAL 2014 FU, 1-azabicyclo[2.2.2] octane,3-(2-propynyloxy)-, (R)-,(E)-2-butenedioate) is devoid of bronchospastic effects in anaesthetized guinea pigs but causes contracture in isolated tracheal muscle from
C Hock et al.
Annals of the New York Academy of Sciences, 920, 285-291 (2001-02-24)
Brain amyloid load in Alzheimer's disease (AD) is, at least in genetic forms, associated with overproduction of amyloid beta-peptides (A beta). Thus, lowering A beta production is a central therapeutic target in AD and may be achieved by modulating such
M Wienrich et al.
Life sciences, 68(22-23), 2593-2600 (2001-06-08)
In functional pharmacological assays, talsaclidine has been described as a functionally preferential M1 agonist with full intrinsic activity, and less pronounced effects at M2- and M3 receptors. In accordance with this, cholinomimetic central activation measured in rabbits by EEG recordings

Artigos

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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