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SRP5256

Sigma-Aldrich

HSP90β, His tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinônimo(s):

D6S182, HSP90AB1, HSP90B, HSPC2, HSPCB

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20 μG
R$ 1.319,00

R$ 1.319,00

Previsão de entrega em16 de abril de 2025

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20 μG
R$ 1.319,00

About This Item

Código UNSPSC:
12352200
NACRES:
NA.32

R$ 1.319,00

Previsão de entrega em16 de abril de 2025

Solicite uma grande encomenda

fonte biológica

human

recombinante

expressed in baculovirus infected Sf9 cells

Ensaio

≥70% (SDS-PAGE)

Formulário

buffered aqueous glycerol solution

peso molecular

~91 kDa

nº de adesão NCBI

NM_ 007355

aplicação(ões)

cell analysis

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... HSP90AB1(3326)

Descrição geral

HSP90β is a member of the HSP90 family of proteins which are important molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, and transport of proteins. HSP90 proteins have been found in a variety of organisms suggesting that they are ancient and conserved. HSP90 binds to client proteins (such as steroid receptors, AKT, Bcr-Abl, Apaf-1, survivin, cyclin dependent kinases) and acts as a molecular chaperone. Failure of Hsp90 chaperone activity leads to misfolding of client proteins, which leads to ubiquitination and proteasome degradation, and thus deregulation of cellular homeostasis.[1]

Ações bioquímicas/fisiológicas

Heat shock protein 90kDa α family class B member 1 (HSP90AB1) is expressed in cancers and has a role in the infection of Japanese encephalitis virus. It also takes part in signal transduction pathways.[2][3][4]

forma física

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

Nota de preparo

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Danger

Frases de perigo

H315,H319,H360D

Classificações de perigo

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
R291-1

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Visite a Biblioteca de Documentos

Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond.
Georgakis GV and Younes A
Future Oncology, 1(2), 273-281 (2005)
Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms
Bin Chen
BMC Genomics, 7, 156-156 (2006)
Yan Zhao et al.
PloS one, 8(3), e58646-e58646 (2013-03-22)
Variations in genetic background are the leading cause of differential susceptibility to traumatic infection. Heat shock protein 90 (HSP90), a broadly distributed and conserved molecule, regulates inflammation under stressful and traumatic conditions. However, the relationships between HSP90 genetic polymorphisms, post-traumatic
Morgan C Hunter et al.
PloS one, 9(1), e86842-e86842 (2014-01-28)
Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved in cell migration and invasion. We used chemical cross-linking and immunoprecipitation followed by tandem mass
Yueh-Liang Tsou et al.
PloS one, 8(10), e77133-e77133 (2013-10-08)
Although several factors participating in enterovirus 71 (EV71) entry and replication had been reported, the precise mechanisms associated with these events are far from clear. In the present study, we showed that heat shock protein 90 (HSP90) is a key

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