SRP4515

Artemin human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Sinônimo(s): ART, ARTN, EVN, NBN
• Número MDL: MFCD03099559
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥98% (SDS-PAGE)
• forma: lyophilized
• potência: 2-5 ng/mL ED₅₀ (it′s ability to stimulate the proliferation of human SH-SY5Y cells)
• peso molecular: ~24 kDa
• embalagem: pkg of 20 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• Impurezas: endotoxin, tested
• nº de adesão NCBI: NM_057090
• nº de adesão UniProt: Q5T4W7
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... ARTN(9048)

Descrição

Descrição geral

Human Artemin, a neurotrophic factor, belongs to the GDNF family. Artemin is a survival factor for sensory and sympathetic neurons in culture. Recombinant human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits. The gene encoding this protein is localized on human chromosome 1p34.1.

Ações bioquímicas/fisiológicas

Artemin (ART/ARTN) is a survival factor for sensory and sympathetic neurons in culture. It has a role in promoting survival of neurons. ART is also involved in the differentiation and development of the central and peripheral nervous systems. The protein promotes axonal projection and migration in sympathetic neurons. Artemin restores neural damage and diminishes neuropathic pain. It has been associated with various carcinomas.

forma física

Lyophilized from 10 mM Sodium Citrate pH 4.5 plus 150 mM NaCl.

Nota de preparo

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstituição

Reconstitute in water to a concentration of 0.1-0.5 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Recontitute in PBS containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/mL. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable