Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

SRP0526

Sigma-Aldrich

B7-1 (CD80), FC Fusion, Biotin Labeled

recombinant, expressed in HEK 293 cells

Sinônimo(s):

CTLA-4 Counter-Receptor B7.1

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

50 μG
R$ 2.664,00

R$ 2.664,00


Previsão de entrega em30 de abril de 2025


Solicite uma grande encomenda

Selecione um tamanho

Alterar visualização
50 μG
R$ 2.664,00

About This Item

Código UNSPSC:
12352202
NACRES:
NA.26

R$ 2.664,00


Previsão de entrega em30 de abril de 2025


Solicite uma grande encomenda

recombinante

expressed in HEK 293 cells

Formulário

frozen liquid

peso molecular

52.5 kDa

nº de adesão UniProt

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... CD8O(941)

Descrição geral

CD80 or B7-1 is expressed in the antigen-presenting cells (APC).[1] The CD80 gene is mapped to human chromosome 3q13.33.[2]
Human secreted B7-1-Fc fusion protein, also known as CD80, with C-terminal Avitag . GenBank Accession No. NM_005191, a.a 35-242 expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avitag technology. MW = 52.5 kDa (monomer). This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

Ações bioquímicas/fisiológicas

CD80 is an efficient costimulatory molecule essential for immune surveillance during carcinogenesis. It inhibits cancer progression.[3] It regulates the T cell activation to control immune response.[1] Cell stress increases the CD80 expression. Reduced expression of CD80 is observed in colon carcinoma. High levels of CD80 stimulate anti-tumor immune responses. Therefore, enhancing CD80 expression in tumors might serve as a potent approach for cancer immunotherapy.[3] Urinary CD80 is recognized as an important biomarker for idiopathic nephrotic syndrome (INS). CD80 might be involved in proteinuria, actin reorganization, and podocyte migration. Its expression in podocytes is associated with minimal change disease (MCD).[1]

forma física

Aqueous solution

Informações legais

AviTag is a trademark of Avidity, LLC

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1


Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documentos section.

Se precisar de ajuda, entre em contato Atendimento ao cliente

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Frank A Schildberg et al.
Immunity, 44(5), 955-972 (2016-05-19)
Immune responses need to be controlled for optimal protective immunity and tolerance. Coinhibitory pathways in the B7-CD28 family provide critical inhibitory signals that regulate immune homeostasis and defense and protect tissue integrity. These coinhibitory signals limit the strength and duration
Gabriel Cara-Fuentes et al.
Pediatric nephrology (Berlin, Germany), 35(10), 1887-1896 (2020-05-14)
Urinary CD80 has emerged as potential biomarker in idiopathic nephrotic syndrome (INS). However, its cellular source remains controversial. The aim of the study was to assess whether CD80 is truly expressed by glomerular cells in INS patients during relapse and
Melania Scarpa et al.
Oncoimmunology, 10(1), 1907912-1907912 (2021-04-20)
CD80 is recognized as one of the most potent costimulatory molecules by which immune cells limit cancer progression; however, the current understanding of the regulation of its expression on human tumor cells is limited. The TP53 tumor suppressor plays a

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica