Human Bromodomain SMARCA2 or BRM (GenBank Accession No. NM_003070) amino-acids 1375 – 1511 with N-terminal HIS-tag, MW = 16.9 kDa, expressed in an E. coli expression system.
Proceedings of the National Academy of Sciences of the United States of America, 109(5), E252-E259 (2012-01-12)
Defining the molecular genetic alterations underlying pancreatic cancer may provide unique therapeutic insight for this deadly disease. Toward this goal, we report here an integrative DNA microarray and sequencing-based analysis of pancreatic cancer genomes. Notable among the alterations newly identified
SWI/SNF (SWItch/sucrose non-fermentable) complexes are ATP-dependent chromatin remodeling enzymes critically involved in the regulation of multiple functions, including gene expression, differentiation, development, DNA repair, cell adhesion and cell cycle control. BRM, a key SWI/SNF complex subunit, is silenced in 15-20%
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