Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos

SML2372

Sigma-Aldrich

β-Muricholic Acid

≥98% (HPLC)

Sinônimo(s):

β-MCA, (3a,5b,6b,7b)-3,6,7-trihydroxy-cholan-24-oic acid, 5β-Cholanic acid-3α,6β,7β-triol, beta-Muricholic Acid

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C24H40O5
Número CAS:
2393-59-1
Peso molecular:
408.57
Número MDL:
MFCD00271403
Código UNSPSC:
12352106
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

atividade óptica

[α]/D +59 to +65°, c = 0.5 in methanol

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear

temperatura de armazenamento

−20°C

InChI

1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13?,14-,15?,16?,17?,18+,20?,21+,22-,23-,24-/m1/s1

chave InChI

DKPMWHFRUGMUKF-CWNVCPLQSA-N

Categorias relacionadas

Aplicação

β-Muricholic Acid has been used as a bile acid to study its effects on the expression of pluripotency, stemness, and inflammatory genes in primary mouse hepatocytes (PMH) and tumor-initiating stem-like cells(TICs). It has also been used as a bile acid to study its effects on gut transit ingnotobiotic or conventional mouse models.

Ações bioquímicas/fisiológicas

β-Muricholic Acid is a naturally occurring trihydroxy hydrophilic bile acid that is produced in the liver of murine. It serves as a biliary cholesterol-desaturating agent and aids in the dissolution of cholesterol gallstones.
β-Muricholic acid (β-MCA) is a natural murine-specific bile acid. β-Muricholic acid has been shown to reduce the absorption of cholesterol. It also has some activity as a farnesoid X receptor antagonist.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 5

1 of 5

Lithocholic acid ≥95%

Sigma-Aldrich

L6250

Lithocholic acid

Taurocholic acid sodium salt hydrate ≥95% (HPLC)

Sigma-Aldrich

T4009

Taurocholic acid sodium salt hydrate

Ácido desoxicólico ≥98% (HPLC)

Sigma-Aldrich

D2510

Ácido desoxicólico

Ursodeoxycholic acid ≥99%

Sigma-Aldrich

U5127

Ursodeoxycholic acid

Sodium taurocholate-2,2,4,4-d4 ≥98 atom % D, ≥98% (CP)

Sigma-Aldrich

900036

Sodium taurocholate-2,2,4,4-d4

Xiaobei Pan et al.
Metabolites, 7(2) (2017-06-21)
Certain endogenous bile acids have been proposed as potential therapies for ameliorating Alzheimer's disease (AD) but their role, if any, in the pathophysiology of this disease is not currently known. Given recent evidence of bile acids having protective and anti-inflammatory
Laura Conde de la Rosa et al.
Journal of hepatology, 74(6), 1429-1441 (2021-01-31)
Besides their physiological role in bile formation and fat digestion, bile acids (BAs) synthesised from cholesterol in hepatocytes act as signalling molecules that modulate hepatocellular carcinoma (HCC). Trafficking of cholesterol to mitochondria through steroidogenic acute regulatory protein 1 (STARD1) is
Kyosuke Fujita et al.
Lipids, 52(4), 335-344 (2017-03-21)
The farnesoid X receptor (FXR) is a major nuclear receptor of bile acids; its activation suppresses sterol regulatory element-binding protein 1c (SREBP1c)-mediated lipogenesis and decreases the lipid contents in the liver. There are many reports showing that the administration of
Ylva Bonde et al.
PloS one, 11(1), e0147772-e0147772 (2016-01-30)
High endogenous production of, or treatment with muricholic bile acids, strongly reduces the absorption of cholesterol. Mice abundant in muricholic bile acids may therefore display an increased resistance against dietary induced weight gain, steatosis, and glucose intolerance due to an
David Q-H Wang et al.
Journal of lipid research, 43(11), 1960-1968 (2002-10-29)
This study investigated whether beta-muricholic acid, a natural trihydroxy hydrophilic bile acid of rodents, acts as a biliary cholesterol-desaturating agent to prevent cholesterol gallstones and if it facilitates the dissolution of gallstones compared with ursodeoxycholic acid (UDCA). For gallstone prevention
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica