SML1873

(2R,6R)-Hydroxynorketamine hydrochloride

≥98% (HPLC)

• Sinônimo(s): (2R,6R)-HNK hydrochloride; (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxy-cyclohexanone hydrochloride
• Fórmula empírica (Notação de Hill): C₁₂H₁₄ClNO₂ · HCl
• Número CAS: 1430202-69-9
• Peso molecular: 276.16
• Número MDL: MFCD30182371
• Código UNSPSC: 12352116
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D -95 to -115°, c = 1 in H₂O
• controle de medicamentos: regulated under CDSA - not available from Sigma-Aldrich Canada
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: 25 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1[C@@](C2=CC=CC=C2Cl)(N)CCC[C@H]1O.Cl

Descrição

Ações bioquímicas/fisiológicas

(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H315,H319
• Declarações de precaução: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable