![1,8-Diazabiciclo[5,4,0]undec-7-eno 98%](/deepweb/assets/sigmaaldrich/product/structures/120/564/5b373e23-1624-489c-8efb-692de0f96ffb/640/5b373e23-1624-489c-8efb-692de0f96ffb.png)
Unfortunately, we do not determine the conformation of this product.
SML0982
Astaxanthin
≥97% (HPLC), powder, PPARγ
Sinônimo(s):
3,3′-Dihydroxy-β-carotene-4,4′-dione, trans-Astaxanthin
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50 MG
R$ 631,00
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50 MG
R$ 631,00
About This Item
Fórmula empírica (Notação de Hill):
C40H52O4
Número CAS:
Peso molecular:
596.84
Código UNSPSC:
12352200
NACRES:
NA.77
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Nome do produto
Astaxanthin, ≥97% (HPLC)
Ensaio
≥97% (HPLC)
Formulário
powder
condição de armazenamento
desiccated
protect from light
cor
, pink to very dark purple
solubilidade
DMSO: 1 mg/mL (warmed)
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
O[C@H]1CC(C(=C(C1=O)C)\C=C\C(=C\C=C\C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)(C)C
InChI
1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1
chave InChI
MQZIGYBFDRPAKN-UWFIBFSHSA-N
Descrição geral
Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.[1]
Aplicação
Astaxanthin has been used:
- as an antioxidant to study its effect on Brachionus manjavacas (Rotifera) population growth[2]
- to study its effects on the treatment of diabetic retinopathy.[2][3]
- to investigate its role in restoring the expression of Nrf2 (nuclear factor erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1) through epigenetic modification in human prostate LNCaP cells.[1]
Ações bioquímicas/fisiológicas
In vivo and in vitro studies propose that astaxanthin (AST) possesses health-promoting activities, signifying its potential use in the prevention of various diseases, such as cancers and Parkinson′s disease.[1] Due to its bright red colour, AST has been used as a food colorant in animal feeds.[3]
Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.
Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory compounds nitric oxide, prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells from oxidative stress generated by TNF-α and palmitate has been shown to ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor of PPARγ.
Outras notas
Light and air sensitive
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Shreya Agrawal et al.
Plant physiology (2021-10-09)
The high-value carotenoid astaxanthin (3,3'-dihydroxy-β,β-carotene-4,4'-dione) is one of the most potent antioxidants in nature. In addition to its large-scale use in fish farming, the pigment has applications as a food supplement and an active ingredient in cosmetics and in pharmaceuticals
Effects of astaxanthin on Brachionus manjavacas (Rotifera) population growth.
Johnston R K, et al.
Aquaculture Research, 49(6), 2278-2287 (2018)
Ningyang Li et al.
Applied microbiology and biotechnology, 104(16), 6977-6989 (2020-07-01)
This study aimed to develop a bioprocess using plant oil as the carbon source for lipid-assimilating yeast to produce high-value astaxanthin. Using high-oleic safflower oil as a model, efficient cell growth and astaxanthin production by the engineered Yarrowia lipolytica strain
Huilin Liu et al.
Marine drugs, 17(3) (2019-03-22)
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. It is a complex process, including a broad spectrum of hepatic lesions from fibrosis to cirrhosis. Our previous study suggested that astaxanthin (AST) could alleviate the hepatic
Effect of astaxanthin on retinal pigment epithelial cells in high glucose: an in-vitro study.
Fu D and Tian X, et al.
Biomedical Research, 28(15) (2017)
Artigos
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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Is the Astaxanthin SML0982 in the 3S, 3'S conformation or is it a mix?
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