SML0865

AA92593

≥98% (HPLC)

• Sinônimo(s): 1-(4-Methoxy-3-methyl-benzenesulfonyl)-piperidine, 1-[(4-Methoxy-3-methylphenyl)sulfonyl]-piperidine, Cy1001
• Fórmula empírica (Notação de Hill): C₁₃H₁₉NO₃S
• Número CAS: 457961-34-1
• Peso molecular: 269.36
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 10 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [S](=O)(=O)(N2CCCCC2)c1cc(c(cc1)OC)C
• InChI: 1S/C13H19NO3S/c1-11-10-12(6-7-13(11)17-2)18(15,16)14-8-4-3-5-9-14/h6-7,10H,3-5,8-9H2,1-2H3
• chave InChI: HDTKLZINZGEPFG-UHFFFAOYSA-N

Descrição

Aplicação

AA92593 has been used as a selective melanopsin inhibitor.[1]

Ações bioquímicas/fisiológicas

AA92593 blocks melanopsin activity and stimulates α-melanocyte-stimulating hormone (α-MSH) expression and induces melanin distribution in the melanophores, which darkens the embryo.[2]

AA92593 is an opsinamide, a potent antagonist of melanopsin-mediated phototransduction with an IC₅₀ of 665 nM in a Ca²⁺ flux assay in CHO cells expressing melanopsin (Opn4) and selectivity > 10 μM at 74 common biological targets. AA41612 is believed to act by competing for binding to melanopsin. AA41612 inhibited mouse pupillary light reflex and light aversion in vivo. AA92593 and similar compounds might be useful in alleviating the photophobia associated with migraine.

AA92593 is an opsinamide, a potent antagonist of melanopsin-mediated phototransduction.

Características e benefícios

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Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable