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SML0761

Sigma-Aldrich

Gossypin

≥90% (HPLC)

Sinônimo(s):

2-(3,4-Dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy- 4H-1-benzopyran-4-one, 3,3′,4′,5,7,8-Hexahydroxyflavone 8-glucoside, Gossypetin 8-glucoside

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About This Item

Fórmula empírica (Notação de Hill):
C21H20O13
Número CAS:
652-78-8
Peso molecular:
480.38
Número MDL:
MFCD00017429
Código UNSPSC:
12352200
ID de substância PubChem:
329825593
NACRES:
NA.77

fonte biológica

Hibiscus vitifolius

Ensaio

≥90% (HPLC)

forma

powder

condição de armazenamento

desiccated

cor

, light yellow to dark green-yellow

solubilidade

DMSO: 15 mg/mL, clear

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3C(=O)C(O)=C(Oc23)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1

chave InChI

SJRXVLUZMMDCNG-KKPQBLLMSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

Gossypin has anti-inflammatory properties. It inhibits galactose-induced cataract formation and reduces β-amyloid-induced toxicity. Gossypin provides protection against carbon tetrachloride-induced toxicity and bis(2-choloroethyl) sulfide-induced dermal toxicity. It also induces apoptosis in myeloma cells. Gossypin has an anticonvulsant property.

Ações bioquímicas/fisiológicas

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Diosmetin

Sigma-Aldrich

D7321

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(±)-Gossypol from cotton seeds ≥95% (HPLC)

Sigma-Aldrich

G8761

(±)-Gossypol from cotton seeds

Mangiferin Mangifera indica

Sigma-Aldrich

M3547

Mangiferin Mangifera indica

Myricetin ≥96.0%, crystalline

Sigma-Aldrich

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Kaempferol ≥90% (HPLC), powder

Sigma-Aldrich

K0133

Kaempferol

Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma
Bhaskaran S, et al.
Molecular Cancer Therapeutics (2013)
Kuei-Chuan Chan et al.
Journal of the science of food and agriculture, 96(2), 381-391 (2015-01-24)
Previous studies have shown that mulberry polyphenolic compounds have an anti-atherosclerotic effect in rabbits. Apoptosis of vascular smooth muscle cells (VSMCs) is the key determinant of the number of VSMCs in remodeling. To examine the effect of mulberry polyphenol extracts
Anticonvulsant activity of bioflavonoid gossypin
Bangladesh Journal of Pharmacology, 4(1), 51-54 (2013)
Gema Núñez-López et al.
Enzyme and microbial technology, 122, 19-25 (2019-01-15)
Fructosylation can significantly improve the solubility, stability and bioactivity of phenolic compounds, increasing their health benefits. Levansucrase from Gluconacetobacter diazotrophicus (LsdA, EC 2.4.1.10) was found to transfer the fructosyl unit of sucrose to different classes of phenolic compounds. Among the
Saad Mustafa et al.
International journal of biological macromolecules, 143, 11-29 (2019-12-08)
Fucoidan, a macromolecule, a type of polysaccharide and contains high percentage of fucose and sulfate ester groups and other compounds in low percentage. In the last decades, a number of interesting biological activities have been studied so fucoidan has been
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