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D7321

Sigma-Aldrich

Diosmetin

Sinônimo(s):

3′,5,7-Trihydroxy-4′-methoxyflavone, 4′-Methylluteolin, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, Luteolin 4′-methyl ether

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About This Item

Fórmula empírica (Notação de Hill):
C16H12O6
Número CAS:
520-34-3
Peso molecular:
300.26
Beilstein:
294492
Número CE:
208-291-8
Número MDL:
MFCD00017425
Código UNSPSC:
12352205
ID de substância PubChem:
329798848
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.

Ensaio

≥98% (HPLC)

Nível de qualidade

200

Formulário

powder

cor

light yellow to yellow

solubilidade

DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow

aplicação(ões)

metabolomics
vitamins, nutraceuticals, and natural products

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2

InChI

1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3

chave InChI

MBNGWHIJMBWFHU-UHFFFAOYSA-N

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Descrição geral

Diosmetin is a methylated aglycone flavone of diosmin.[1] It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves[2], and in the legume of Acacia farnesiana tree.[1]

Aplicação

Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.[2]

Ações bioquímicas/fisiológicas

Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties.[2] It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).[3]
Flavonoid from Citrus limon. Antioxidant. Inhibits carcinogen activation by inhibiting the CYP1A1 enzyme.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
WXBF2100V
WXBD9478V
SLCH8896
SLCF3620
SLCF0149

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Chrysin ≥96.5%

Sigma-Aldrich

C80105

Chrysin

Hesperidin analytical standard

Supelco

50162

Hesperidin

Apigenin ≥97% (TLC), from citrus

Sigma-Aldrich

SMB00702

Apigenin

Hesperidin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1794

Hesperidin

Qinmei Liu et al.
Biomolecules & therapeutics, 26(2), 157-166 (2017-04-04)
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse lung inflammation with high mortality rates and limited therapeutic methods. Diosmetin, an active component from Chinese herbs, has long been noticed because of its antioxidant
Elham Saghaei et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 5725361-5725361 (2021-01-09)
In the present experimental study, male NMRI mice were exposed to chronic unpredictable mild stress (CUMS) paradigm for 35 days. Diosmetin (at doses of 10, 20, and 40 mg/kg. i.p.) or diosmetin solvent (normal saline + DMSO, 1 ml/kg; i.p.) was administered 30 min before
A review on pharmacological and analytical aspects of diosmetin: a concise report.
Patel, et al.
Chinese Journal of Integrative Medicine, 19, 792-800 (2018)
Miguel Angel Campanero et al.
Journal of pharmaceutical and biomedical analysis, 51(4), 875-881 (2009-10-06)
Diosmetin (3',5,7-trihydroxy-4'-methoxyflavone) is the aglycone of the flavonoid glycoside diosmin (3',5,7-trihydroxy-4'-methoxyflavone-7-ramnoglucoside). Diosmin is hydrolyzed by enzymes of intestinal micro flora before absorption of its aglycone diosmetin. A specific, sensitive, precise, accurate and robust HPLC assay for the simultaneous determination of
Beatriz Abad-García et al.
Rapid communications in mass spectrometry : RCM, 22(12), 1834-1842 (2008-05-13)
Six flavone mono-C-glucosides, four standards (beta-D-glucopyranosyl-(1 --> C-6)- and -(1 --> C-8)- apigenin and luteolin) and two others from lemon juice (beta-D-glucopyranosyl-(1 --> C-6)- and -(1 --> C-8)-diosmetin) have been studied in order to analyze their fragmentation patterns. Initial separation
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