SML0305

3-Deazaneplanocin A hydrochloride

≥97% (HPLC)

• Sinônimo(s): (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride, DZNep hydrochloride
• Fórmula empírica (Notação de Hill): C₁₂H₁₄N₄O₃ · HCl
• Número CAS: 120964-45-6
• Peso molecular: 298.73
• Número MDL: MFCD18782644
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825310
• NACRES: NA.77

Propriedades

• Ensaio: ≥97% (HPLC)
• Formulário: powder
• atividade óptica: [α]/D -88 to -108°, c = 0.1 in water
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: ≥5 mg/mL
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Cl.Nc1nccc2n(cnc12)[C@@H]3C=C(CO)[C@@H](O)[C@H]3O
• InChI: 1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/m1./s1
• chave InChI: UNSKMHKAFPRFTI-FDKLLANESA-N

Descrição

Descrição geral

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic property.[1] It is used to treat Ebola virus disease,[2] gastric cancer, myeloma and lymphoma.[3]

Aplicação

3-Deazaneplanocin A hydrochloride has been used to examine the potential involvement of autophagy and apoptosis in colorectal cancer (CRC) cells.[4]

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression.[5] It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.[6]

Ações bioquímicas/fisiológicas

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

3-Deazaneplanocin A is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor.

Características e benefícios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable