SML0277

Methylnaltrexone bromide

≥97% (HPLC)

• Sinônimo(s): 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide, MNTX, Methylnaltrexonium, Mrz-2663, N-Methylnaltrexone, Naltrexone MB, Quaternary ammonium naltrexone
• Fórmula empírica (Notação de Hill): C₂₁H₂₆NO₄ · Br
• Número CAS: 73232-52-7
• Peso molecular: 436.34
• Número MDL: MFCD06407831
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825285
• NACRES: NA.77

Propriedades

• Ensaio: ≥97% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: ≥5 mg/mL
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Br-].C[N@+]1(CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@]2(O)CCC4=O)c35)CC6CC6
• InChI: 1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1
• chave InChI: IFGIYSGOEZJNBE-KNLJMPJLSA-N
• Informações sobre genes: human ... OPRM1(4988)

Descrição

Descrição geral

Methylnaltrexone does not cross blood brain barrier and does not affect the opioid effects in the brain, such as analgesia.[1] It is used to treat opioid-induced constipation (OIC).[2]

Aplicação

Methylnaltrexone bromide has been used as a drug to measure plasma protein binding (PPB), permeability (Pm) and the membrane coefficient (KIAM) for the prediction of blood brain barrier (BBB) penetration.[3] It is also used as a mu-opioid receptor (MOR) antagonist to abrogate morphine tolerance and opioid-induced hyperalgesia (OIH).[4]

Ações bioquímicas/fisiológicas

Methylnaltrexone bromide is a narcotic antagonist.

Methylnaltrexone bromide is a narcotic antagonist. It is a peripheral mu-opiod receptor antagonist that cannot cross the blood-brain barrier. It reverses many opioid side-effects without interfering with pain relief.

Características e benefícios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Warning
• Frases de perigo: H371
• Declarações de precaução: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Classificações de perigo: STOT SE 2 Oral
• Órgãos-alvo: Gastrointestinal tract
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable