SBR00121

Amphotericin B water soluble

from semisynthetic, powder

• Sinônimo(s): AmB, Amphotericin
• Fórmula empírica (Notação de Hill): C₅₁H₈₂N₂O₁₉
• Peso molecular: 1027.20
• Código UNSPSC: 51302401

Propriedades

• fonte biológica: fermentation/recombinant; semisynthetic
• Nível de qualidade: 200
• Ensaio: ≥90% (HPLC)
• forma: powder
• condição de armazenamento: protect from light
• cor: light yellow to very dark yellow, to very dark brown
• Modo de ação: cell membrane | interferes
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• adequação: fungi; yeasts
• InChI: 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• chave InChI: APKFDSVGJQXUKY-INPOYWNPSA-N

Descrição

Descrição geral

Amphotericin B is a polyene antifungal antibiotic which has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Amphotericin B water soluble is a synthetic derivative of AmB that preserves the antifungal activity but is highly miscible in water up to 100 mg/mL.

Ações bioquímicas/fisiológicas

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. Antimicrobial spectrum: Includes fungi and yeast It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium. Amphotericin B is most effective against fungi and yeast.

Características e benefícios

Easily soluble in water up to 100mg/mL
Animal component free
Tested for cell toxicity
Aseptically packaged
Can be 0.2µm filtered

Nota de preparo

Amphotericin B water soluble can be directly dissolved in the media to a working concentration of 2.5 mg/L.

Outras notas

Product is sensitive to light.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H372
• Declarações de precaução: P260 - P264 - P270 - P314 - P501
• Classificações de perigo: STOT RE 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable