SAB4503824
Anti-phospho-p130 Cas (pTyr410) antibody produced in rabbit
affinity isolated antibody
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 93 kDa
reatividade de espécies
mouse, rat, human
concentração
~1 mg/mL
técnica(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
phosphorylation (pTyr410)
Informações sobre genes
human ... BCAR1(9564)
Categorias relacionadas
Descrição geral
Breast cancer antiestrogen resistance 1 (BCAR1), also known as p130 Cas, is encoded by the gene mapped to human chromosome 16q23. BCAR1 belongs to Cas (Crk-associated substrate) protein family. The protein is characterized with an amino-terminal Src homology 3 (SH3) domain, a Src-binding domain, a large substrate domain, and a helix-loop-helix domain.
Imunogênio
The antiserum was produced against synthesized peptide derived from human p130 Cas around the phosphorylation site of Tyr410.
Immunogen Range: 376-425
Immunogen Range: 376-425
Ações bioquímicas/fisiológicas
Breast cancer antiestrogen resistance 1 (BCAR1), also known as p130 Cas, plays a vital role in various cellular processes such as migration, adhesion, cytoskeleton reorganization host-pathogen interaction, survival, proliferation, transformation, and possibly metastasis. It is associated with the growth factor receptor EGFR and the metastasis suppressor KAI1, in vitro. Overexpression of BCAR1 in localized prostate cancers (LPC) suggests that this protein has potential as a marker for both prognosis and treatment. It is also considered to be a potential marker for breast cancer. Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) and BCAR1, via SRC, promote removal of E-Cadherin from cell membrane, and trigger E-cadherin degradation.
Características e benefícios
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forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Gaëlle Fromont et al.
The Prostate, 67(3), 268-273 (2006-12-29)
The 16q23 locus has been recently suggested in both breast and prostate cancer to contain a gene involved in disease progression. The breast cancer antiestrogen resistance 1 (BCAR1) gene, located at 16q23, contributes to many cellular processes including migration and
Lambert C J Dorssers et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(18 Pt 1), 6194-6202 (2004-09-28)
BCAR1, the human homologue of the rat p130Cas protein, was identified in a functional screen for human breast cancer cell proliferation resistant to antiestrogen drugs. Here, we study the prognostic value of quantitative BCAR1 levels in a large series of
Nadezhda Tikhmyanova et al.
PloS one, 6(7), e22102-e22102 (2011-07-19)
The Cas scaffolding proteins (NEDD9/HEF1/CAS-L, BCAR1/p130Cas, EFSSIN, and HEPL/CASS4) regulate cell migration, division and survival, and are often deregulated in cancer. High BCAR1 expression is linked to poor prognosis in breast cancer patients, while upregulation of NEDD9 contributes to the
Bo Deng et al.
Annals of surgical oncology, 20 Suppl 3, S701-S708 (2013-08-02)
This study was designed to determine the prognostic value of BCAR1 expression and its associations with clinical-demographical characteristics in multiple centers of non-small cell lung cancer (NSCLC) patients. Gene expression microarray (mRNA) of 77 adenocarcinomas from Mayo Clinic, RNA-sequencing of
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