SAB4503757

Anti-phospho-CREB (pSer¹⁴²) antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen 36 kDa
• reatividade de espécies: human, mouse, rat
• concentração: ~1 mg/mL
• técnica(s): ELISA: 1:40000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• nº de adesão NCBI: P16220
• nº de adesão UniProt: P16220
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pSer142)
• Informações sobre genes: human ... CREB1(1385)

Descrição

Descrição geral

CREB1 (cAMP response element-binding protein) gene codes for a 43kDa cellular transcription factor, CREB. It has 341 amino acids. It belongs to the basic leucine zipper family of transcription factors. CREB1 is upregulated abundantly in human tissues and is located on human chromosome 2q33–35.

Imunogênio

The antiserum was produced against synthesized peptide derived from human CREB around the phosphorylation site of Ser142.

Immunogen Range: 111-160

Ações bioquímicas/fisiológicas

Knockdown of CREB (cAMP response element-binding protein) promotes apoptosis in pre-B acute lymphoblastic leukemia cells by preventing prosurvival signals. It controls the transcription of antiapoptotic proteins in several cell types. Decrease in CREB phosphorylation leads to malfunction of mitochondria and hypoxia-induced apoptosis in chondrocytes.

Características e benefícios

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forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable