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SAB4502631

Sigma-Aldrich

Anti-Actin-pan antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

ACTA, ACTA1, ACTS, Actin α skeletal muscle

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 41 kDa

reatividade de espécies

rat, mouse, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

P68032

nº de adesão UniProt

P68032

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ACTA1(58)

Descrição geral

Anti-Actin-pan antibody detects endogenous levels of total actin-pan protein.
The ACTA1 (actin, α1) gene is mapped to human chromosome 1q42.13. The gene codes for actin 1, a thin filament component of skeletal muscle.

Imunogênio

The antiserum was produced against synthesized peptide derived from human Actin.

Immunogen Range: 21-70

Ações bioquímicas/fisiológicas

Mutations in ACTA1 (actin, α1) is known to cause thin filament myopathy, such as nemaline myopathy, congenital myopathy, actin myopathy, intranuclear rod myopathy, cap myopathy and core myopathy. Upregulation of the gene is observed in orthotopic liver transplantation without any earlier evidence of autoimmune liver disease. The encoded protein actin forms a network of filaments and is responsible for the shape of the cell. It provides cellular strength and promotes active movement of the cell.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases.
Pellegrini L
BioMed Research International, 2017, 1-7 (2017)
Guosheng Luo et al.
Medical oncology (Northwood, London, England), 39(8), 111-111 (2022-06-07)
The ubiquitination process, which involves that binding of an ubiquitin protein to certain substrates, regulates several human biological processes and human cancers. Several studies report that the abnormal expression of quite a few E3 ubiquitin ligases could play critical role
Prevalence and phenotypes of congenital myopathy due to ?-actin 1 gene mutations.
Witting N
Muscle and Nerve, 53(3), 388-393 (2016)
Mutation-specific effects on thin filament length in thin filament myopathy.
Winter JM
Annals of Neurology, 79(6), 959-969 (2016)
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.
Hansen SD and Mullins RD
eLife, 4, 1-29 (2015)
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