SAB4502076

Anti-Parkin antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): PARK2, PRKN, PRKN2, Parkinson disease protein 2, Parkinson juvenile disease protein 2
• Número MDL: MFCD02263896
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen 51 kDa
• reatividade de espécies: human
• concentração: ~1 mg/mL
• técnica(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• nº de adesão NCBI: O60260
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... PRKN2(5071)

Descrição

Descrição geral

The PRKN (parkin RBR E3 ubiquitin protein ligase) gene, also referred to as PARK2, is mapped to human chromosome 6q25.2–27. It is one of the largest genes in the human genome spanning a length of 1.53Mb. The gene consists of 12 exons and encodes a protein of 465 amino acids. It is broadly expressed in several tissues, including neurons, astrocytes, lung, colon and testes.

Anti-Parkin Antibody detects endogenous levels of total Parkin protein.

Imunogênio

The antiserum was produced against synthesized peptide derived from human Parkin.

Immunogen Range: 101-150

Ações bioquímicas/fisiológicas

The PRKN (parkin RBR E3 ubiquitin protein ligase) gene encodes an E3 ubiquitin ligase that is involved in the maintenance of dopamine (DA) neuronal homeostasis. It ubiquitinates target proteins by interacting with ubiquitin-conjugating enzymes, such as UBCH7 (Ubiquitin-conjugating enzyme E2 L3) and UBCH8 (Ubiquitin/ISG15-conjugating enzyme E2 L6). Mutations in this gene have been linked to early-onset and progression of Parkinson′s Disease. Variations in this gene have also been associated with glioblastoma and other human malignancies.

Características e benefícios

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forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable