SAB4200420

Anti-Lamin A, mature antibody, Mouse monoclonal

clone 4A4, purified from hybridoma cell culture

• Sinônimo(s): Anti-LMN1, Anti-LMNA, Anti-Lamin A/C, Anti-Prelamin-A/C, Monoclonal Anti-Lamin A, mature antibody produced in mouse
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: purified from hybridoma cell culture
• tipo de produto de anticorpo: primary antibodies
• clone: 4A4, monoclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen ~72 kDa
• reatividade de espécies: human
• validação aprimorada: independent; Learn more about Antibody Enhanced Validation
• concentração: ~1.0 mg/mL
• técnica(s): indirect immunofluorescence: 0.25-0.5 μg/mL using human HeLa cells; western blot: 0.25-0.5 μg/mL using whole extracts of human HeLa cells
• Isotipo: IgG1
• nº de adesão UniProt: P02545
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... LMNA(4000)

Descrição

Descrição geral

Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.

Imunogênio

synthetic peptide corresponding to the C-terminus of mature human Lamin A.

Aplicação

Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.

Ações bioquímicas/fisiológicas

Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable