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SAB3500395

Sigma-Aldrich

Anti-PDL-2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

PDL2 Antibody - Anti-PDL-2 antibody produced in rabbit, Pdl2 Antibody, Anti-B7DC, Anti-PD-L2, Anti-Programmed cell death 1 ligand-2, Anti-Programmed death ligand 1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

predicted mol wt 30 kDa

reatividade de espécies

human, rat, mouse

técnica(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

nº de adesão NCBI

NP_079515

nº de adesão UniProt

Q9BQ51

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... PDCD1LG2(80380)

Descrição geral

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as butyrophilin B7-DC or CD273. It belongs to the immunoglobulin superfamily. The gene encoding PDL-2 is localized on human chromosome 9p24.1.

Imunogênio

PDL-2 antibody was raised against a 16 amino acid peptide from near the center of human PDL-2.

Aplicação

Anti-PDL-2 antibody produced in rabbit has been used in immunohistochemistry.

Ações bioquímicas/fisiológicas

The expression of programmed cell death 1 ligand 2 (PD-L2) or CD antigen 273 (CD273) is up-regulated by interferon-γ (IFNG/IFN-γ) stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with colony-stimulating factor-2 (CSF2) and interleukin-4 (IL-4). PD-L2 is involved in the co-stimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligação

The action of this antibody can be blocked using blocking peptide SBP3500395.

forma física

Supplied in PBS with 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation
Katharina P
European Journal of Immunology (2006)
PD-1, PD-L1 and PD-L2 expression in mouse prostate cancer
Shijie Yang
American Journal of Clinical Nutrition (2016)
Hamidah Muhamad et al.
Acta haematologica, 143(1), 78-88 (2019-07-23)
The programmed cell death 1/programmed cell death ligands (PD-1/PD-Ls) axis is a potential immune escape mechanism of cancers. However, data on the PD-1/PD-Ls pathway in EBV-associated extranodal natural killer/T cell lymphoma (ENKTL) and its clinical implication are limited. Herein, we
Carlo Sorrentino et al.
Frontiers in immunology, 12, 778329-778329 (2022-01-04)
Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing impact on public health and clinical management. Immunotherapy has shown promise in the treatment of advanced cancers, but needs to be improved for CRC, since only
Misung Yi et al.
BMC bioinformatics, 24(1), 298-298 (2023-07-23)
Protein biomarkers of cancer progression and response to therapy are increasingly important for improving personalized medicine. Advanced quantitative pathology platforms enable measurement of protein expression in tissues at the single-cell level. However, this rich quantitative cell-by-cell biomarker information is most
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