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SAB1405747

Sigma-Aldrich

Anti-EGR2 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Sinônimo(s):

AT591, CMT1D, CMT4E, DKFZp686J1957, FLJ14547, KROX20

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen ~50.3 kDa

reatividade de espécies

human

técnica(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

nº de adesão NCBI

NM_000399.2

nº de adesão UniProt

P11161

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... EGR2(1959)

Categorias relacionadas

Descrição geral

Early growth response 2 (EGR2) is a zinc finger transcription factor and a member of the EGR family. Structurally, it comprises activation domain(A), DNA binding domain (DBD) zinc finger domain, basic domain (BD) and broadly neutralizing antibody (BNab) interaction domain(R1). The EGR2 gene is mapped to human chromosome 10q21.3.

Imunogênio

EGR2 (NP_000390.2, 1 a.a. ~ 476 a.a) full-length human protein.

Sequence
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

Ações bioquímicas/fisiológicas

Early growth response 2 (EGR2) is essential for peripheral nerve myelination and T cell anergy. It is also needed for the formation of gap junction beta 1 (GJB1) and periaxin along with other myelin proteins. Mutations in the EGR2 gene are implicated in peripheral neuropathies namely Charcot-Marie-Tooth disease type 1 (CMT1), congenital hypomyelinating neuropathy (CHN), and Dejerine-Sottas neuropathy (DSN/CMT). EGR2 upregulation may regulate inflammatory cytokines during recovery from Guillain-Barré syndrome (GBS).

forma física

Solution in phosphate buffered saline, pH 7.4

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Kota Noritsugu et al.
Biochemical and biophysical research communications, 489(4), 455-459 (2017-06-04)
EGR2 is a zinc finger transcription factor that regulates myelination in the peripheral nervous system and T cell anergy. The transcriptional activity of EGR2 is known to be regulated by its co-activators and/or co-repressors. Although the activity of transcription factors
Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3 and EGR2 on chromosome 10.
B Van Der Zwaag et al.
Journal of medical genetics, 39(6), E30-E30 (2002-06-19)
Ernesto Doncel-Pérez et al.
Journal of immunology (Baltimore, Md. : 1950), 196(3), 1102-1107 (2016-01-01)
Guillain-Barré syndrome (GBS) is an immune-mediated peripheral neuropathy. The goal of this research was the identification of biomarkers associated with recovery from GBS. In this study, we compared the transcriptome of PBMCs from a GBS patient and her healthy twin
Roseline Poirier et al.
Frontiers in neuroscience, 2(1), 47-55 (2008-11-05)
The different gene members of the Egr family of transcriptional regulators have often been considered to have related functions in brain, based on their co-expression in many cell-types and structures, the relatively high homology of the translated proteins and their
Bianca R Grosz et al.
Scientific reports, 9(1), 19336-19336 (2019-12-20)
EGR2 (early growth response 2) is a crucial transcription factor for the myelination of the peripheral nervous system. Mutations in EGR2 are reported to cause a heterogenous spectrum of peripheral neuropathy with wide variation in both severity and age of

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