S8559

Sinefungin

95% (HPLC), powder, methylation of bases in DNA & RNA inhibitor

• Sinônimo(s): 5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine, A-9145, Adenosylornithine, Antibiotic 32232RP
• Fórmula empírica (Notação de Hill): C₁₅H₂₃N₇O₅
• Número CAS: 58944-73-3
• Peso molecular: 381.39
• Código UNSPSC: 12352200
• ID de substância PubChem: 24899800
• NACRES: NA.77

Propriedades

• Nome do produto: Sinefungin, 95% (HPLC), powder
• Nível de qualidade: 200
• Ensaio: 95% (HPLC)
• Formulário: powder
• cor: white to yellow
• solubilidade: H₂O: complete 20 mg/ml, clear, colorless to light yellow; H₂O: soluble
• espectro de atividade do antibiótico: neoplastics
• Modo de ação: DNA synthesis | interferes; enzyme | inhibits
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
• chave InChI: LMXOHSDXUQEUSF-YECHIGJVSA-N

Descrição

Descrição geral

Chemical structure: nucleoside

Aplicação

Sinefungin was used to inhibit global methyltransferases in breast cancer cell line, MCF7² and Jurkat cells.³ It was used as S-adenosylmethionine analogue in equilibrium FRET experiments.⁴

Ações bioquímicas/fisiológicas

Blocks the methylation of bases in DNA and RNA; involved in physiological processes such as aging and carcinogenesis.

Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.

Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.
Methylation inhibition by sinefugin is often accompanied by an altered rate of cytosine deamination that is coupled to transition mutation in the DNA. Sinefugin inhibits Epstein-Barr viral activity and this inhibition is related to the change in DNA methylation and gene expression. It can cause a rate change in several restriction DNA endonuclease activities, including Mme I, which is not connected to the inhibition of the methytransferase activity.

Características e benefícios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves